Registro completo |
Provedor de dados: |
Ciência Rural
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País: |
Brazil
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Título: |
Multi-drug resistance gene (MDR1) and opioid analgesia in horses
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Autores: |
Natalini,Cláudio Corrêa
Cunha,Anderson Fávaro da
Linardi,Renata Lehn
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Data: |
2006-02-01
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Ano: |
2006
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Palavras-chave: |
Molecular biology
Opioids
Equine
Gene
MDR1
ABCB1
Analgesia
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Resumo: |
Opioid absorption in the intestinal tract as well as its effects in the central nervous system is modulated by the P-glycoprotein (P-gp) encoded in the Multi-drug Resistance gene (MDR1) also named ATP-binding cassete, subfamily B, member 1 (ABCB1). This MDR1 gene acts as a selective pump. The expression of this protein in humans and rodents inhibits cellular uptake of substrate opioids. The presence of the intestinal iso-enzyme CYP3A4 associated with MDR1 gene decreases the opioid analgesic activity due to an increase in intestinal metabolism, with a predicted intestinal first pass extraction around 20% which significantly influences the oral availability of opioids. In the central nervous system, P-gp expression decreases opioid neuronal uptake diminishing the analgesic effects. It is unknown if horses have the MDR1 gene and P-gp and what are the effects on opioid absorption, metabolism, and analgesia. Identifying the MDR1 gene and P-gp status in horses is of great importance in order to better understand opioid pharmacologic effects in horses.
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Tipo: |
Info:eu-repo/semantics/article
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Idioma: |
Inglês
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Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100055
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Editor: |
Universidade Federal de Santa Maria
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Relação: |
10.1590/S0103-84782006000100055
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Formato: |
text/html
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Fonte: |
Ciência Rural v.36 n.1 2006
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Direitos: |
info:eu-repo/semantics/openAccess
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